DOXYCYCLINE is a tetracycline antibiotic. It kills certain bacteria or stops their growth. It is used to treat many kinds of infections, like dental, skin, respiratory, and urinary tract infections. It also treats acne, Lyme disease, malaria, and certain sexually transmitted infections. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Use Doryx Delayed-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Doryx Delayed-Release Capsules by mouth with or without food. If stomach upset occurs, take with food or milk to reduce stomach irritation.
Swallow Doryx Delayed-Release Capsules whole. Do not break, crush, or chew before swallowing.
Drink plenty of fluids with Doryx Delayed-Release Capsules to wash it down. This will also help to decrease the risk of throat irritation from Doryx Delayed-Release Capsules.
If you cannot swallow the capsule whole, you may open it and sprinkle the contents over a spoonful of applesauce. Do not use hot applesauce. Mix the medicine with the applesauce and swallow the mixture right away, followed by a glass of water. Do not crush or chew the medicine before swallowing. Do not store the mixture for future use.
Do not take an antacid that has aluminum, magnesium, or calcium in it; sodium bicarbonate; or bismuth salts (eg, bismuth subsalicylate) within 2 hours of taking Doryx Delayed-Release Capsules.
To clear up your infection completely, take Doryx Delayed-Release Capsules for the full course of treatment. Keep taking it even if you feel better in a few days.
If you are taking Doryx Delayed-Release Capsules to prevent malaria, you should begin to take it 1 to 2 days before you travel to the malaria-infected area. You will need to keep taking it for 4 weeks after you leave the area. Discuss any questions with your doctor.
Do not use Doryx Delayed-Release Capsules if it is outdated or has been stored incorrectly.
If you miss a dose of Doryx Delayed-Release Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Doryx Delayed-Release Capsules.
Important safety information:
Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.
Be sure to use Doryx Delayed-Release Capsules for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
Doryx Delayed-Release Capsules only works against bacteria; it does not treat viral infections (eg, the common cold).
Long-term or repeated use of Doryx Delayed-Release Capsules may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
If you are taking Doryx Delayed-Release Capsules to prevent malaria, please note that no malaria medicine, including Doryx Delayed-Release Capsules, guarantees protection against malaria. Stay in well-screened areas, use mosquito nets, cover the body with clothing, and use insect repellant to avoid being bitten by mosquitoes.
Doryx Delayed-Release Capsules may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Doryx Delayed-Release Capsules. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or blood stools occur. Do not treat diarrhea without first checking with your doctor.
Tell your doctor or dentist that you take Doryx Delayed-Release Capsules before you receive any medical or dental care, emergency care, or surgery.
Doryx Delayed-Release Capsules may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Doryx Delayed-Release Capsules.
Doryx Delayed-Release Capsules should not be used in CHILDREN younger than 8 years old; permanent yellow-gray-brown tooth discoloration may occur.
Hormonal birth control (eg, birth control pills) may not work as well while you are using Doryx Delayed-Release Capsules. To prevent pregnancy, use an extra form of birth control (eg, condoms).
PREGNANCY and BREAST-FEEDING: Doryx Delayed-Release Capsules has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Doryx Delayed-Release Capsules while you are pregnant. Doryx Delayed-Release Capsules are found in breast milk. Do not breast-feed while taking Doryx Delayed-Release Capsules.
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Accupril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme.
Accupril is used to treat high blood pressure (hypertension) and heart failure.
Accupril may also be used for purposes other than those listed in this medication guide.
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Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Take each dose with a full glass of water.
Accupril can be taken with or without food.
Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. This can lead to very low blood pressure, electrolyte disorders, or kidney failure while you are taking Accupril. Drink plenty of water each day while you are taking this medication.
To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Accupril. You may need to stop using the medicine for a short time.
If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.
Store Accupril at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a Accupril overdose may include feeling extremely dizzy or light-headed, or fainting.
What should I avoid while taking Accupril?
Avoid drinking alcohol. It can further lower your blood pressure and may increase some of the side effects of Accupril. Do not use salt substitutes or potassium supplements while taking Accupril, unless your doctor has told you to.
Accupril side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
feeling light-headed, fainting;
urinating more or less than usual, or not at all;
fever, chills, body aches, flu symptoms;
pale skin, easy bruising or bleeding;
severe blistering, peeling, and red skin rash;
tired feeling, muscle weakness, and pounding or uneven heartbeats;
chest pain;
swelling, rapid weight gain; or
jaundice (yellowing of the skin or eyes).
Less serious side effects may be more likely to occur, such as:
cough;
muscle pain;
dizziness, drowsiness, headache;
nausea, vomiting, diarrhea; or
mild skin itching or rash.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
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Product info: General Health
Accutane (ISOTRETINOIN) is a drug used for the treatment of severe, disfiguring cystic acne that has not cleared up in response to milder medications such as antibiotics.
It works on the oil glands within the skin, shrinking them and diminishing their output. Accutane derives from vitamin A and is found in small quantities naturally in the body.
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Due to the possibly significant negative side effects of Accutane, the drug is normally used as a last resort when other forms of acne treatment including the use of over the counter products or prescription antibiotics have not been successful in treating the acne.
Before using
Accutane is a naturally occurring derivative of vitamin A and is detectable in the bloodstream of all people. Vitamin A in large doses has the same effects as Accutane, both good and bad, but quickly becomes harmful since it builds up in the tissue. (Important: Don't take any vitamin A while on Accutane). Accutane is formed naturally in the body from the Vitamin A present in the bloodstream. This is why large amounts of Vitamin A taken during pregnancy cause the same birth defects that Accutane does. Fortunately, because it is a naturally occurring product, the body is able to quickly remove Accutane from the bloodstream. It is gone from the blood within nine days and has no lasting effect on future pregnancies.
Do not start or stop any medicine without doctor or pharmacist approval. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
Directions
Follow the directions for using this medicine provided by your doctor. This medicine is usually taken two times a day with a meal, unless your doctor tells you otherwise. Swallow the capsule. Don't suck or chew it. Take it with a full glass of water, milk, or other nonalcoholic liquid. Follow your doctor's instructions carefully.
Depending on your reaction to Accutane, your doctor may need to adjust the dosage upward or downward. If you respond quickly and very well, your doctor may take you off Accutane even before the 15 or 20 weeks are up.
After you finish taking Accutane, there should be at least a 2-month "rest period" during which you are off the drug. This is because your acne may continue to get better even though you are no longer taking the medication. Once the 2 months are up, if your acne is still severe, your doctor may want to give you a second course of Accutane. If you are still growing, your doctor may recommend a longer "rest period."
The recommended dosage range for Accutane is 0.5 to 1 milligram per 2.2 pounds of body weight, divided into 2 doses daily, for 15 to 20 weeks. For very severe cases, the doctor may increase the daily dose to as much as 2 milligrams per 2.2 pounds.
If after a period of 2 months or more off therapy, severe cystic acne persists, your doctor may prescribe a second course of therapy
Cautions
Accutane is a potentially dangerous prescription medicine that should only be taken under the close supervision of your healthcare professional and pharmacist. If you are pregnant or may get pregnant, accutane can cause birth defects, miscarriage, premature births, and death in babies.
Avoid consumption of alcoholic beverages.
Read the patient information leaflet available with the product.
Do not crush the capsules.
Do not share Accutane with anyone because of the risk of birth defects and other serious side effects.
Possible side effects
Unfortunately, side effects depend on the dose as well. At the lowest doses, there are almost no side effects at all. At the highest, everyone get rather nasty side effects, which are related on the drying effects on the oil glands. The dose needs to be adjusted to strike a balance between effectiveness and side effects.
Side effects are listed here. Abnormal hair growth or loss, allergic reaction, bleeding gums, blood in urine, bowel inflammation and pain, bruising, changes in blood sugar or cholesterol levels, changes in skin pigmentation, chest pain, decreased night vision, decreased tolerance to contact lenses, delay in wound healing, depression, difficulty sleeping, dizziness, drowsiness, dry or fragile skin, dry or cracked lips, dry mouth, dry nose, fatigue, flushing, headache, hearing problems, heartbeat irregularities, herpes, inflammation or sores in the esophagus, itching, joint pain, liver disorders, menstrual changes, muscle wasting, nail disorders, nausea, nervousness, nosebleeds, peeling palms or soles, pinkeye, rash, skin infections, stomach and intestinal discomfort, stroke, sudden drop in blood pressure (causing unconsciousness), sunburn-sensitive skin, suppression of growth, sweating, swelling due to fluid retention, tendon and ligament problems, urinary discomfort, vision problems, vomiting, weakness, weight loss
Accutane may increase the level of blood fats, sometimes to risky levels. This reverts back to normal when the drug is stopped. Occasionally it may affect the liver. That's why regular blood tests are necessary during Accutane treatment. There is little risk of any damage if these precautions are followed.
The most damaging side effect of Accutane is serious birth defects if taken during pregnancy. It is critically important for women not to take Accutane while pregnant, and not to become pregnant while taking it. Women who are, or might be, sexually active while taking Accutane must use an effective method of birth control, of which the birth control pill is the most effective. Birth control pills do rarely fail, so an additional method of birth control such as a condom for the male partner or a spermicidal foam or sponge is also needed. Because the birth defects caused by Accutane are so serious, it's important not to share the pills with others.
If you take too much
Any medication taken in excess can have serious consequences. If you suspect an overdose of Accutane, seek medical attention immediately.
• Overdosage of Accutane, like overdosage of vitamin A, can cause:
Abdominal pain, dizziness, dry or cracked lips, facial flushing, incoordination and clumsiness, headache, vomiting
Additional information
While taking Accutane, do not take vitamin supplements containing vitamin A. Accutane and vitamin A are chemically related; taking them together is like taking an overdose of vitamin A.
Remember, too, that Accutane should not be combined with tetracycline antibiotics such as Doryx, Minocin, and Vibramycin.
Drug interactions
The concurrent use of Accutane with tetracycline antibiotics or vitamin A supplementation is not recommended. Concurrent use of isotretinoin with tetracyclines significantly increases the risk of idiopathic intracranial hypertension. Concurrent intake of Vitamin A supplementation increases the risk of vitamin A toxicity.
Concurrent use of isotretinoin with methotrexate increases the risk of hepatotoxicity and may increase methotrexate levels. The combination is used with caution and close monitoring of adverse effects and liver function tests.
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